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Clinical Trials Search at Vanderbilt-Ingram Cancer Center

Sparing Bone Marrow in Patients with Stage III-IV Lung Cancer, VMAT Trial

This phase II trial tests whether designing radiation to avoid bone marrow in the spine (vertebral bone marrow) leads to less reduction of white blood cell counts (lymphopenia) in patients with lung cancer. This sparing technique could lead to better disease control and outcome.
Not Available
Not Available
Osmundson, Evan
Vanderbilt University


18 Years
Inclusion Criteria:

Adult patient >= 18 years

Patients with American Joint Committee on Cancer (American Joint Committee on Cancer [AJCC] 8) T1-T4, N1-N3, M0 stage IIIA-IIIC non-small cell lung cancer (NSCLC)

Patients with oligometastatic disease stage IV, M1 disease, in which definitive concurrent chemoradiotherapy to the thorax is planned

Absolute lymphocyte count > 500/ml

Hemoglobin > 8 g/dL

Aspartate aminotransferase (AST)/Alanine aminotransferase (ALT)
Eastern Cooperative Oncology Group (ECOG) 0-2

Exclusion Criteria:

History of thoracic irradiation

History of palliative radiation for the current malignancy under consideration

Patients not being treated with definitive standard of care to the chest

History of bone marrow disease and or leukemia

History of prior cytotoxic chemotherapy for a disease other than for the current malignancy

Polymetastatic disease, defined here as >= 3 or more extrathoracic metastases

Administration of concurrent immunotherapy during radiation therapy, either as part of another clinical trial or otherwise

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