Clinical Trials Search at Vanderbilt-Ingram Cancer Center
Comparing an Alternative Surgical Procedure, Sentinel Lymph Node (SLN) Biopsy, with Standard Neck Dissection for Patients with Early-Stage Oral Cavity Cancer
Head/Neck
Head/Neck
This phase II/III trial studies how well sentinel lymph node biopsy works and compares sentinel lymph node biopsy surgery to standard neck dissection as part of the treatment for early-stage oral cavity cancer. Sentinel lymph node biopsy surgery is a procedure that removes a smaller number of lymph nodes from your neck because it uses an imaging agent to see which lymph nodes are most likely to have cancer. Standard neck dissection, such as elective neck dissection, removes many of the lymph nodes in your neck. Using sentinel lymph node biopsy surgery may work better in treating patients with early-stage oral cavity cancer compared to standard elective neck dissection.
Head/Neck
II/III
Topf, Michael
NCT04333537
NRGHN006
An Imaging Agent (89Zr Panitumumab) with PET/CT for Diagnosing Primary Lesions and/or Metastases in Patients with Head and Neck Squamous Cell Carcinoma
Head/Neck
Head/Neck
This phase I trial evaluates the usefulness of an imaging agent (zirconium Zr 89 panitumumab [89Zr panitumumab]) with positron emission tomography (PET)/computed tomography (CT) for diagnosing primary tumors and/or the spread of disease from where it first started (primary site) to other places in the body (metastasis) in patients with head and neck squamous cell carcinoma. 89Zr panitumumab is an investigational imaging agent that contains a small amount of radiation, which makes it visible on PET scans. PET is an established imaging technique that utilizes small amounts of radioactivity attached to very minimal amounts of tracer, in the case of this research, 89Zr panitumumab, to allow imaging of the function of different cells and organs in the body. CT utilizes x-rays that traverse the body from the outside. CT images provide an exact outline of organs and potential disease tissue where it occurs in patients body. The combined PET/CT scanner is a special type of scanner that allows imaging of both structure (CT) and function (PET) following the injection of 89Zr panitumumab. This 89Zr panitumumab PET/CT may be useful in diagnosis of primary tumors and/or metastasis in patients with head and neck squamous cell carcinoma.
Head/Neck
I
Topf, Michael
NCT05747625
VICCHN2279
Virtual Patient-Specific 3D Specimen Maps for Adjuvant Head & Neck Radiotherapy Planning
Head/Neck
Head/Neck
This study measures the impact of patient-specific 3D specimen maps on adjuvant radiation treatment volumes and doses to critical organs.
Head/Neck
N/A
Topf, Michael
NCT05743569
VICCHN22102
Impact of DHT on Swallowing Physiology in HNCa Patients
Head/Neck
Head/Neck
Head/Neck
N/A
Topf, Michael
VICCHN2102
Laryngeal Cancer Treatment Decision-Making: A Conjoint Analysis of Post-Treatment Priorities
Not Available
N/A
Topf, Michael
VICCHN2201
Intraoral 3D Scanning of Head and Neck Resection Beds: a Feasibility Study.
Head/Neck
Head/Neck
Head/Neck
N/A
Topf, Michael
VICCHN2259
Virtual 3D Scanning and Intraoperative Communication System and Video Library for Head and Neck Surgical Specimens.
Head/Neck
Head/Neck
Head/Neck
N/A
Topf, Michael
VICCHN2272
Virtual 3D Intraoperative Communication System for Orthopedic Oncology: A Feasibility Study
Head/Neck
Head/Neck
Head/Neck
N/A
Topf, Michael
VICC-VDHAN23197
Biomarker-Driven Radiation Therapy Dose Reduction after Transoral Robotic Surgery for the Treatment of HPV-Positive Oropharyngeal Cancer
Head/Neck
Head/Neck
This phase II trial tests whether reduced dose radiation therapy after transoral robotic surgery works in treating patients with human papillomavirus (HPV)-positive oropharyngeal cancer. HPV positive oropharyngeal cancer has a better prognosis than oropharyngeal cancer not caused by HPV. A standard of care treatment for HPV positive oropharyngeal cancer is transoral robotic surgery followed by radiation therapy. However, this treatment is associated with many long-term side effects including difficulty swallowing. Radiation therapy uses high energy rays to kill tumor cells and shrink tumors. Giving reduced dose radiation therapy after transoral robotic surgery may improve swallowing outcomes and quality of life compared to standard of care dose radiation therapy after transoral robotic surgery.
Head/Neck
II
Topf, Michael
NCT05387915
VICC-ITHAN23125
