Translational_Research_and_Interventional_Oncology_Research_Program News
Multi-institutional study of Wilms tumor facilitates enrollment, optimizes treatment Enrollment and outcomes were similar across racial and ethnic groups for children participating in therapeutic trials for Wilms tumor — the most common pediatric kidney cancer worldwide, according to a recent report in the Journal of the American College of Surgeons. Tuesday, February 27th, 2024 |
|
Molecular Profiles of Tissue Plus Circulating Tumor DNA Can Better Guide Cancer Care The current standard of care for identifying targetable mutations in cancer treatment is to conduct molecular profiles on tumor tissue samples, but a study published Monday in JAMA Network Open authored by Wade Iams, MD, and colleagues indicates that adding liquid biopsy testing for circulating tumor DNA mutations increases targetable mutation detection rates. Thursday, February 1st, 2024 |
|
3D Ingenuity: Surgeon develops visual aid for real-time pathology consults Michael Topf, MD, Assistant Professor of Otolaryngology-Head and Neck Cancer Surgery at Vanderbilt wondered why computer-aided design (CAD) technology hadn’t made it into operating rooms as a visual aid for real-time consultations... So he decided to create it. Thursday, February 1st, 2024 |
|
Exceptional Growth for Amyloidosis Care When the Vanderbilt Amyloid Multidisciplinary Program (VAMP) launched in 2011, it was the first center in Tennessee dedicated to patients with amyloidosis – a rare, systemic disorder that encompasses myriad presentations and organ dysfunctions. Since then, VAMP has paved the way to coordinated care as a major referral center in the southeastern United States, growing to include over a dozen collaborating specialists working to provide structured, multidisciplinary care to adults navigating an amyloidosis diagnosis. Wednesday, January 31st, 2024 |
|
New members of Academy for Excellence in Clinical Medicine selected Vanderbilt University School of Medicine Academy for Excellence in Clinical Medicine (AECM) has selected 25 new members. Friday, December 15th, 2023 |
|
3D Ingenuity Three-dimensional scanning and printing systems are now utilized for purposes ranging from same-day dental crowns to prosthetic limbs, so Michael Topf, MD, wondered why computer-aided design (CAD) technology hadn’t made it into operating rooms as a visual aid for real-time consultations. Surgeons communicate via phone and are dependent upon verbal descriptions from pathologists for guidance […] Thursday, November 30th, 2023 |
|
Innovative Therapy Boosts Survival in Myelodysplastic Syndrome Researchers find that ASTX727, a new oral combination therapy, can prolong survival in TP53-mutated MDS. Monday, November 6th, 2023 |
|
Being treated for childhood cancer set Jason Schwartz on the path to his life’s work: treating childhood cancer At the ripe age of 13, Jason Schwartz made a life-changing decision. Amid cancer treatment for Acute Lymphoblastic Leukemia (ALL), Schwartz was handed an incredible gift that would fuel his life’s work. Wednesday, September 27th, 2023 |
|
AI to Address Questions Left by Lung Screenings Research team refines method for diagnosis of indeterminant lung nodules using artificial intelligence and advanced learning. Wednesday, August 23rd, 2023 |
|
New leaders named to Vanderbilt-Ingram research programs Seven new leaders have been appointed to guide Vanderbilt-Ingram Cancer Center's research programs. Thursday, August 10th, 2023 |
|
Marshaling First-Line Immunotherapy for CRC Kristen Ciombor, M.D., reflects on recent wins and opportunities ahead in the precision targeting of colorectal cancer. Wednesday, July 26th, 2023 |
|
Stronger Hearts for Childhood Cancer Survivors Pediatric oncologists and cardiologists collaborate on reducing cardiotoxic effects of cancer treatment. Wednesday, June 7th, 2023 |
|
Target for Lung-Cancer Subtype Identified Multifaceted study connects early amplified oncogene MDM2 with outcomes and therapy responses. Wednesday, June 7th, 2023 |
|
Genomic analysis of SCLC tumors reveals subtypes, offers cues toward personalized treatments The largest genomic analysis ever conducted of small cell lung cancer tumors (SCLC) has identified genetic subtypes and provided insights into the mechanisms of this aggressive and deadly cancer. Thursday, May 11th, 2023 |
|
Trial combines novel therapies for head and neck cancer Vanderbilt is launching a clinical trial that pairs an experimental vaccine with an established immunotherapy for recurrent, human papilloma virus (HPV)-related oropharyngeal cancer of the head and neck. Thursday, April 27th, 2023 |
|
Vanderbilt-Ingram devises CAR T treatment protocol without hospital stay Oluwole’s patients often call him “Dr. O,” and he is one of the nation’s top CAR T experts. He is an author of a study published in The New England Journal of Medicine in 2017 that showed CAR T is an effective treatment for refractory large B-cell lymphoma. Thursday, April 6th, 2023 |
|
VUMC researcher selected for Global Scholars Program Vanderbilt researcher P. Brent Ferrell, MD, is leading one of five projects selected by the 2022 Novartis Institutes for BioMedical Research Global Scholars Program. Thursday, March 30th, 2023 |
|
Researchers discover molecular signature for aggressive thyroid cancer A Vanderbilt study found that a molecular signature that predicts aggressive thyroid cancer could help guide treatment approaches for patients. Sunday, February 5th, 2023 |
|
VUMC researchers upend dogma about vasopressin production Vanderbilt investigators have discovered that vasopressin, which has long been thought to be produced only in the brain, is also produced in the kidney. Thursday, January 5th, 2023 |
|
Convalescent plasma improved survival in COVID-19 patients with blood cancers Treatment with convalescent plasma vastly improved the survival rate of patients hospitalized for COVID-19 who also had hematologic malignances that compromise the immune system, according to new data released by the COVID-19 and Cancer Consortium (CCC19). Friday, February 5th, 2021 |
|
VUMC, Case Western apply artificial intelligence to “customize” oral cancer treatment Researchers at Vanderbilt University Medical Center and Case Western Reserve University in Cleveland have been awarded a five-year, $3.3 million grant by the National Cancer Institute to apply artificial intelligence (AI) to help customize treatment for oral cancer patients. Tuesday, January 5th, 2021 |
|
Rini to lead NCI study of COVID-19 in cancer patients Brian Rini, MD, is leading a study launched by the National Cancer Institute (NCI) that will closely monitor cancer patients who acquire COVID-19 with the goal of providing highly detailed data to guide future care. Thursday, October 29th, 2020 |
|
Lovly to chair foundation’s scientific leadership board Christine Lovly, MD, PhD, Ingram Associate Professor of Cancer Research, has been named incoming chair of GO2 Foundation’s Scientific Leadership Board (SLB). Thursday, October 29th, 2020 |
|
Grant bolsters Weiss’ pediatric thyroid cancer research Vivian Weiss, MD, PhD, has been named a 2020 V Scholar and will receive $200,000 from the V Foundation for Cancer Research. Thursday, November 7th, 2019 |
|
Study identifies targeted therapy’s cardiac risks After a recent study showed that chronic lymphocytic leukemia patients who received ibrutinib as a frontline treatment had a 7% death rate, a new study offers a clearer picture on the reasons for the deaths. Thursday, October 3rd, 2019 |
|
New prostate cancer treatment concept Combining immunotherapy and radiation therapy may be a powerful treatment approach for castration-resistant prostate cancer. Friday, August 30th, 2019 |
|
Grant bolsters research on myelodysplastic syndromes Michael Savona, MD, professor of Medicine and Cancer Biology, and director of Hematology Research at Vanderbilt-Ingram Cancer Center, has received a competitive grant award from the Edward P. Evans Foundation. Friday, August 9th, 2019 |
|
Encephalitis identified as rare toxicity of immunotherapy treatment Researchers are chronicling rare but serious toxicities that may occur with immune checkpoint inhibitors, the most widely prescribed class of immunotherapies. Monday, July 22nd, 2019 |
|
Childhood cancer: how it’s different than for adults The nature of childhood cancer is different than adult cancer, and so is the approach to treatment. Saturday, June 29th, 2019 |
|
Combination therapy improves small-cell lung cancer survival Patients who received atezolizumab in addition to standard chemotherapy lived two months longer than those treated with chemotherapy alone, according to a recent study published in the New England Journal of Medicine. Friday, October 26th, 2018 |
|
Liquid biopsies help reveal lung cancer mutations Cancer investigators led by researchers at Vanderbilt-Ingram Cancer Center have co-developed a liquid biopsy blood-based assay used to identify specific gene mutations associated with the development or relapse of small-cell lung cancer (SCLC) Thursday, November 2nd, 2017 |
|
Horn to lead lung cancer combination therapy trial Leora Horn, M.D., M. Sunday, April 2nd, 2017 |
|
Study details rare heart risk of certain cancer therapies Combination therapy using two approved immunotherapy drugs for cancer treatment may cause rare and sometimes fatal cardiac side effects linked to an unexpected immune response. In a study led by Vanderbilt University Medical Center (VUMC) investigators and published in the Nov. 3 issue of the New England Journal of Medicine, researchers describe two cases of […] Monday, November 7th, 2016 |
|
VICC trial putting lung cancer therapy to the test Vanderbilt-Ingram Cancer Center (VICC) is leading a Phase 3 global trial of a cancer therapy that was initially tested and validated in a VICC research laboratory. One of the first patients treated with the therapy came to VICC after a bump on the head led to an unexpected cancer diagnosis. That head injury may have […] Thursday, October 20th, 2016 |
|
New prostate cancer therapy investigated at VUMC Vanderbilt University Medical Center is the world’s first site to treat a patient in the TULSA-PRO Ablation Clinical Trial (TACT), which employs an emerging therapy that uses MRI guidance and robotically driven therapeutic ultrasound to obtain precise prostate cancer tissue ablation. Investigators, David Penson, M.D. Thursday, September 22nd, 2016 |
|
VICC treats first patient in Tennessee with novel cellular immunotherapy For the first time, Vanderbilt-Ingram Cancer Center (VICC) investigators have used a cancer patient’s own re-engineered immune cells to treat a form of blood cancer by stimulating the immune system. The new CAR-T investigational therapy (known as KTE-C19) is being studied in a clinical trial for patients with aggressive non-Hodgkin Lymphoma (NHL). The trial, called […] Monday, February 29th, 2016 |
|
$51 million NIH grant brings ELVIS to VUMC Vanderbilt University Medical Center scientists are launching a research platform called ELVIS that is devoted to molecular underpinnings of early-childhood determinants of health. Tuesday, September 19th, 0023 |