Yu Shyr, Ph.D.
- Associate Director for Quantitative Sciences
- Harold L. Moses Professor of Cancer Research
- Chair, Department of Biostatistics
- Professor of Biostatistics, Biomedical Informatics, and Health Policy
- Director, Vanderbilt Center for Quantitative Sciences (CQS) and VANGARD
- Scientific Director, Quantitative Sciences Shared Resource
Phone
2220 Pierce Ave.
571 Preston Building
Nashville, TN 37232-6848
Yu Shyr, Ph.D.
- Associate Director for Quantitative Sciences
- Harold L. Moses Professor of Cancer Research
- Chair, Department of Biostatistics
- Professor of Biostatistics, Biomedical Informatics, and Health Policy
- Director, Vanderbilt Center for Quantitative Sciences (CQS) and VANGARD
- Scientific Director, Quantitative Sciences Shared Resource
615-936-2572
yu.shyr@vumc.org
2220 Pierce Ave.
571 Preston Building
Nashville, TN 37232-6848
Research Program
-
Non-Programmatically Aligned
Departments/Affiliations
Profile
Yu Shyr received his PhD in biostatistics from the University of Michigan (Ann Arbor) in 1994 and subsequently joined the faculty at Vanderbilt University School of Medicine. At Vanderbilt, he has collaborated on numerous research projects; assisted investigators in developing clinical research protocols; collaborated on multiple grants funded through external peer-reviewed mechanisms; and developed biostatistical methodologies for clinical trial design, high-dimensional data preprocessing, and other statistical approaches, published in journals such as Statistics in Medicine, Bioinformatics, and Clinical Trials in the last three years.
Dr. Shyr is a Fellow of the American Statistical Association and an FDA advisory committee voting member. He has delivered more than 190 abstracts at professional meetings and has published more than 300 peer-reviewed papers. Dr. Shyr has served on numerous NIH/NCI SPORE, P01, and CCSG review panels/committees and has been a member of the invited faculty at the AACR/ASCO Methods in Clinical Cancer Research Vail Workshop since 2004. He currently serves on the external advisory board for a dozen national cancer centers, and directs the biostatistics and bioinformatics cores for the NCI-funded Vanderbilt University Breast Cancer SPORE, GI Cancer SPORE, and other program projects. In addition, Dr. Shyr is the Principle Investigator of a UO1 grant for the Barrett's esophagus translational research network coordinating center (BETRNetCC). Dr. Shyr's current research interests focus on developing statistical bioinformatic methods for analyzing next-generation sequencing data including a series of papers on estimating the sample size requirements for studies conducting RNA sequencing analysis.
Education
- Ph.D., University of Michigan, Ann Arbor, Michigan (1994)
- M.S., Michigan State University, East Lansing, Michigan (1989)
- B.B.A., Tamkang University, Tamsui, Taiwan (1985)
Research Emphasis
statistical bioinformatics, big data, high-dimensional data processing, clinical trial design, sample size estimation, next-generation sequencing
Research Description
Yu Shyr received his Ph.D. in biostatistics from the University of Michigan and subsequently joined the faculty at Vanderbilt University School of Medicine. He is the Harold L. Moses Chair in Cancer Research, founding director of both the Vanderbilt Center for Quantitative Sciences (CQS) and Vanderbilt Technologies for Advanced Genomics Analysis and Research Design (VANGARD), as well as professor of biostatistics, biomedical informatics, cancer biology and health policy.
Dr. Shyr is a Fellow of the American Statistical Association and FDA advisory committee voting member. He has delivered more than 200 abstracts at professional meetings and published more than 400 peer-reviewed papers in a variety of journals (h-index = 83). He is the member of the US National Academy of Medicine (IOM) Committee on Policy Issues in the Clinical Development of Biomarkers for Molecularly Targeted Therapies. He has served as a member of the US National Cancer Institute (NCI) Developmental Therapeutics Study Section, Cancer Immunopathology and Immunotherapy Study Section and the Population and Patient-oriented Training Study Section; he also has served on the epidemiology section of the U.S. Army Medical Research and Materiel Command Breast Cancer Research Program (BCRP), and Dr. Shyr is the co-course director for the AACR/ASCO Methods in Clinical Cancer Research Vail Workshop. In addition, he has presented workshops worldwide, in countries such as Belgium, Canada, Germany, China, Japan, Saudi Arabia, and Taiwan. He currently serves on 14 external advisory boards, is the associate editor of JAMA Oncology and the Journal of Thoracic Oncology, directs the biostatistics/bioinformatics cores for the NCI-funded Vanderbilt University Breast Cancer SPORE and GI Cancer SPORE, and is the principle investigator of the NCI U01 Barrett’s Esophagus Translational Research Network Coordinating Center (BETRNetCC).
Publications
- Shaver TM, Lehmann BD, Beeler JS, Li CI, Li Z, Jin H, Stricker TP, Shyr Y, Pietenpol JA. Diverse, Biologically Relevant, and Targetable Gene Rearrangements in Triple-Negative Breast Cancer and Other Malignancies. Cancer Res [print-electronic]. 2016 Aug 8/15/2016; 76(16): 4850-60. PMID: 27231203, PII: 0008-5472.CAN-16-0058, DOI: 10.1158/0008-5472.CAN-16-0058, ISSN: 1538-7445.
- Blum A, Venkitachalam S, Guo Y, Kieber-Emmons AM, Ravi L, Chandar AK, Iyer PG, Canto MI, Wang JS, Shaheen NJ, Barnholtz-Sloan JS, Markowitz SD, Willis JE, Shyr Y, Chak A, Varadan V, Guda K. RNA Sequencing Identifies Transcriptionally-Viable Gene Fusions in Esophageal Adenocarcinomas. Cancer Res [print-electronic]. 2016 Aug 8/8/2016; PMID: 27503924, PII: 0008-5472.CAN-16-0979, DOI: 10.1158/0008-5472.CAN-16-0979, ISSN: 1538-7445.
- Gilchuk P, Hill TM, Guy C, McMaster SR, Boyd KL, Rabacal WA, Lu P, Shyr Y, Kohlmeier JE, Sebzda E, Green DR, Joyce S. A Distinct Lung-Interstitium-Resident Memory CD8(+) T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection. Cell Rep [print-electronic]. 2016 Aug 8/3/2016; PMID: 27498869, PII: S2211-1247(16)30955-X, DOI: 10.1016/j.celrep.2016.07.037, ISSN: 2211-1247.
- Eilertson B, Maruri F, Blackman A, Guo Y, Herrera M, van der Heijden Y, Shyr Y, Sterling TR. A novel resistance mutation in eccC5 of the ESX-5 secretion system confers ofloxacin resistance in Mycobacterium tuberculosis. J. Antimicrob. Chemother [print-electronic]. 2016 Jun 6/3/2016; PMID: 27261264, PII: dkw168, DOI: 10.1093/jac/dkw168, ISSN: 1460-2091.
- Matsushita K, Yang HC, Mysore MM, Zhong J, Shyr Y, Ma LJ, Fogo AB. Effects of combination PPAR¿ agonist and angiotensin receptor blocker on glomerulosclerosis. Lab. Invest [print-electronic]. 2016 Jun; 96(6): 602-9. PMID: 26999660, PII: labinvest201642, DOI: 10.1038/labinvest.2016.42, ISSN: 1530-0307.
- Vilgelm AE, Johnson CA, Prasad N, Yang J, Chen SC, Ayers GD, Pawlikowski JS, Raman D, Sosman JA, Kelley M, Ecsedy JA, Shyr Y, Levy SE, Richmond A. Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment. J. Natl. Cancer Inst [electronic-print]. 2016 Jun; 108(6): djv406. PMID: 26719346, PMCID: PMC4849355, PII: djv406, DOI: 10.1093/jnci/djv406, ISSN: 1460-2105.
- Sheng Q, Zhao S, Li CI, Shyr Y, Guo Y. Practicability of detecting somatic point mutation from RNA high throughput sequencing data. Genomics [print-electronic]. 2016 May; 107(5): 163-9. PMID: 27046520, PII: S0888-7543(16)30021-0, DOI: 10.1016/j.ygeno.2016.03.006, ISSN: 1089-8646.
- Zhang P, Samuels DC, Wang J, Zhao S, Shyr Y, Guo Y. Mitochondria single nucleotide variation across six blood cell types. Mitochondrion [print-electronic]. 2016 May; 28: 16-22. PMID: 26956645, PII: S1567-7249(16)30011-3, DOI: 10.1016/j.mito.2016.03.001, ISSN: 1872-8278.
- Marshall CB, Mays DJ, Beeler JS, Rosenbluth JM, Boyd KL, Santos Guasch GL, Shaver TM, Tang LJ, Liu Q, Shyr Y, Venters BJ, Magnuson MA, Pietenpol JA. P73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network. Cell Rep [print-electronic]. 2016 Mar 3/15/2016; 14(10): 2289-300. PMID: 26947080, PMCID: PMC4794398, PII: S2211-1247(16)30138-3, DOI: 10.1016/j.celrep.2016.02.035, ISSN: 2211-1247.
- Jordan LC, Gindville MC, Scott AO, Juttukonda MR, Strother MK, Kassim AA, Chen SC, Lu H, Pruthi S, Shyr Y, Donahue MJ. Non-invasive imaging of oxygen extraction fraction in adults with sickle cell anaemia. Brain [print-electronic]. 2016 Mar; 139(Pt 3): 738-50. PMID: 26823369, PII: awv397, DOI: 10.1093/brain/awv397, ISSN: 1460-2156.
