Jeffrey Rathmell, PhD, founding director of the Vanderbilt Center for Immunobiology and a pioneer in immune and cancer cell metabolism research, this summer will begin a new chapter in his career at the University of Chicago.

University officials announced March 3 that Rathmell has been named chair of the Ben May Department for Cancer Research and director of the Ludwig Center at the University of Chicago, effective July 1.

Rathmell currently holds the Cornelius Vanderbilt Chair in Immunobiology and is professor of Pathology, Microbiology and Immunology, and of Molecular Physiology and Biophysics in the Vanderbilt University School of Medicine.

“Dr. Rathmell’s impact on immunology and cancer metabolism research at Vanderbilt has been remarkable,” said Jennifer Pietenpol, PhD, Chief Scientific and Strategy Officer and Executive Vice President for Research at Vanderbilt University Medical Center.

“His leadership in building an immunology community, advancing translational research and mentoring the next generation of scientists has left a legacy,” said Pietenpol, who holds the Brock Family Directorship in Career Development. “While we will greatly miss his leadership at Vanderbilt, we know his impact will expand in these prestigious roles at the University of Chicago and the Ludwig Center.”

The Ludwig Center at the University of Chicago, one of six Ludwig Centers nationwide, is focused on finding ways to stop the spread of cancer.

Rathmell earned his PhD in immunology from Stanford University, did postdoctoral work in immunology and cancer biology at the University of Chicago and University of Pennsylvania, and was on the faculty at Duke University before coming to Vanderbilt in 2015.

As director of the Vanderbilt Center for Immunobiology, he has led growth in basic science and translational immunology at Vanderbilt, with an emphasis on the research of immune-related diseases and building an immunology community.

A co-leader of the Host-Tumor Interactions Program in the Vanderbilt-Ingram Cancer Center, Rathmell helped define the metabolic mechanisms that control inflammatory diseases and cancer.

He also led initiatives, as associate director of the Molecular Pathology and Immunology PhD Program and of the Vanderbilt Institute for Infection, Immunology and Inflammation, to strengthen basic science immunology education and position Vanderbilt as a leader in immunology research.

Rathmell said he is looking forward to working in collaboration with the University of Chicago Comprehensive Cancer Center to advance understanding of the tumor microenvironment and the role that immunity plays in cancer growth and response to therapy.

The post Jeffrey Rathmell named to leadership role in cancer research at the University of Chicago appeared first on VUMC News.

Many Medicare patients with advanced cancer receive potentially aggressive treatment at the expense of supportive care, according to a study that analyzed Medicare records. 

The study, published Feb. 21 in JAMA Health Forum, examined the quality of end-of-life care among 33,744 Medicare decedents. The study involved patients of diverse ethnic backgrounds age 66 or older who died from breast, prostate, pancreatic or lung cancers.  

Overall, claims records showed that 45% of the patients experienced potentially aggressive care (such as multiple acute care visits within days of death), while there was a low receipt of supportive care, such as palliative, hospice and advanced care planning in the last six months of life. While hospice care spiked to more than 70% during the month that death occurred, over 16% of patients spent less than three days in hospice care. Moreover, receipt of advanced care planning and palliative care remained below 25%. 

“Care at end-of-life continues to favor overtreatment despite considerable efforts to raise awareness about the harms of aggressive treatment in the last decade,” said Youngmin Kwon, PhD, a research fellow with the Department of Health Policy at Vanderbilt University Medical Center.  

Access to supportive care varied among demographic groups. Patients who were older, non-Hispanic white, had longer survival durations, or lived in rural areas, as well as areas with lower socioeconomic levels, were less likely to receive supportive care. 

“For dying patients and their caregivers, hospice is often considered the gold standard of end-of-life that can holistically manage care needs,” the authors noted. “The fact that a considerable portion did not use hospice care at all or entered into hospice care within three days of death suggests the potential benefits of hospice care were not realized for many patients.” 

The findings underscore the need for multifaceted efforts to optimize the quality of end-of-life care for cancer patients. 

 “Having clear and honest communication between patients, their caregivers and providers regarding disease prognosis and advanced planning is crucial,” said Kwon. “At the same time, policies to increase access to supportive care and ensure an adequate workforce of palliative care providers are necessary to address structural barriers to high-quality care.” 

The post Study shows end-of-life cancer care lacking for Medicare patients  appeared first on VUMC News.

Appendiceal cancer is a rare cancer without standardized screening guidelines, risk factors or tumor classifications — a situation that often results in late diagnosis and poor prognosis.  

Up to 1 of every 2 patients is diagnosed with distant metastatic disease, and five-year survival rates vary between 10% and 63%. A team of experts has identified six key research priority areas to deliver a fundamental understanding of appendiceal tumors and to improve treatments and outcomes for patients. Research to advance treatments for this rare cancer is critical.

The recommendations published Feb. 13 in Nature Reviews Cancer are the result of a concerted focus by the Appendix Cancer Pseudomyxoma Peritonei (ACPMP) Research Foundation to better understand the disease that afflicts an estimated 3,000 new patients across all age groups each year. The incidence could be higher because of the challenges accurately diagnosing the disease and identifying the tumor type, the researchers noted.

“The rising burden of appendiceal cancer has illuminated the rudimentary knowledge gaps — spanning from genomes to generations — in our understanding of this rare cancer. By establishing this first-ever research ‘road map’ for appendiceal tumors, we aim to drive collaborative and transformative research discoveries that ultimately will lead to improvements in disease detection, diagnosis, treatments and outcomes for our patients,” said Andreana Holowatyj, PhD, MSCI, assistant professor of Medicine at Vanderbilt University Medical Center and chair of the Scientific Advisory Board for the ACPMP Research Foundation, the article’s lead author.

The recommendations arose from the inaugural ACPMP Research Foundation Scientific Think Tank, sponsored by ACPMP and chaired by Holowatyj at Vanderbilt-Ingram Cancer Center in December 2023. The Think Tank showcases the benefits for scientific collaborations, for robust investments in rare cancer research, and for informing evidence-based medicine. The ongoing effort continues to be a catalyst for revolutionizing the field of research for appendix cancer.

Twenty leading experts on appendiceal cancer met at the Think Tank, and a study group from that meeting are authors of the article.

“This Think Tank and the subsequent publication mark a watershed moment for appendix cancer research,” said Deborah Shelton, JD, Executive Director of ACPMP Research Foundation and co-author of the article. “For far too long, appendix cancer has remained underfunded and underresearched, leaving patients with limited options. These research priorities provide a clear path forward, and ACPMP is committed to ensuring the necessary funding and resources to propel these efforts.”

The six research priorities:

• Refining histopathological classification – Appendix tumors are not a single entity. Variability of terminology for appendix tumor classification is a challenge due to the rarity of the cancer and supports the need for expert pathology review of appendix tumors among all patients. Consistent application of tumor classification and grading, digitizing histology for tumor detection, and leveraging computational approaches to refine tumor diagnosis are needed.
• Molecular characterization of appendix tumors – The discovery of appendix tumor cells most often occurs postappendectomy when the entire appendix has been removed prior to cancer diagnosis. Preserving and molecular profiling of this tissue are necessary to establish a composite multiomics view of appendiceal tumors.
• Defining the appendiceal tumor microenvironment – A better understanding of the dynamic ecosystem surrounding tumor cells will yield new information for treating appendiceal cancer as well as understanding tumor evolution and disease progression. This information should also be used to contribute to a molecular atlas for appendix tumors.
• Development of disease-specific models – The number of appendix tumor models is extremely limited. Research continues on developing patient-derived organoids to support preclinical testing of new therapeutic drugs.
• Clinical studies of appendix tumors – Collaborative, multicenter efforts — such as the Genetics of Appendix Cancer (GAP) Study at Vanderbilt-Ingram, as well as the development of clinical trials in appendix tumors will yield evidence-based, clinically impactful advancements in this rare cancer.
• Appendix cancer on a population level – Population studies will help researchers identify potential risk factors and/or exposures associated with appendix tumors and address distinct care needs of patients with appendix tumors. These studies will deliver key data to establish early detection strategies, support clinical trials, improve clinical practice and impact public policy.

The study’s other authors include Michael Overman, MD, Konstantinos Votanopoulos, MD, PhD, Andrew Lowy, MD, Patrick Wagner, MD, Mary Kay Washington, MD, PhD, Cathy Eng, MD, Wai Chin Foo, MD, Richard Goldberg, MD, Mojgan Hosseini, MD, Kamran Idrees, MD, MSCI, MMHC, Douglas Johnson, MD, MSCI, Ardaman Shergill, MD, Erin Ward, MD, and Nicholas Zachos, PhD.

Their work was supported by the ACPMP Research Foundation, Vanderbilt-Ingram Cancer Center and NIH/NCI (P50CA236733).

The post Experts publish action plan to address appendiceal cancer enigmas appeared first on VUMC News.

Yi Rens most recent paper published in eLife describes the structure of a protein complex involved in mRNA export that sheds light on the underlying molecular mechanism of mRNA export and the role it plays during infection by herpes viruses.

Vanderbilt researchers have developed a new nanoparticle that can more effectively get drugs inside of cells to boost the immune system and fight diseases like cancer.

A multidisciplinary research team at Vanderbilt University and Vanderbilt University Medical Center has discovered a new way to kill a tumor by disrupting its acidic microenvironment without harming normal tissue.

A multidisciplinary team of investigators has received a 2023 Endeavor Award from The Mark Foundation for Cancer Research to support four closely linked projects exploring the fundamental mechanisms that drive the obesity-cancer connection

Chemical and biomedical engineer and cancer researcher Marjan Rafat has received the Young Innovator Award from the Cellular and Molecular Bioengineering division of the Biomedical Engineering Society. The CMBE Young Innovator Award is a distinguished honor for young faculty in the biomolecular engineering field.

Vanderbilts Center for Technology Transfer and Commercialization named Richard Caprioli C. David Weaver Susan Eagle and Franz Baudenbacher 2023 Master Innovators. The yearly recognition program acknowledges Vanderbilts top innovators and entrepreneurs for their contributions to the creation development and commercialization of intellectual property.

Vanderbilt engineering professor Justus Ndukaife is leading innovative research that more effectively traps nanosized extracellular vesicles and particles to analyze their roles in cancer and neurodegenerative diseases.