Four researchers at Vanderbilt-Ingram Cancer Center have assumed new leadership roles. 

Shared resources at Vanderbilt-Ingram are designed to support and enhance cancer-relevant research and scientific interaction by providing access to cutting-edge technologies and services, as well as scientific expertise.

Scott Hiebert, PhD, emeritus professor of Biochemistry and the Hortense B. Ingram Chair in Cancer Researchat Vanderbilt University, led these shared resources in the Cancer Center from 2010 to 2025. With his retirement from Vanderbilt University, Ben Ho Park, MD, PhD, director of Vanderbilt-Ingram, has appointed William Tansey, PhD, Ingram Professor of Cancer Research and professor of Cell and Developmental Biology, as the next associate director for Shared Resources for Vanderbilt-Ingram.  

As associate director for Shared Resources, Tansey will oversee 10 resources, including animal and human imaging, bioanalytics and proteomics, chemical synthesis and high-throughput analytics, cell imaging, data science, flow cytometry, genome editing, genomic sciences, survey and biospecimen, and translational pathology. In addition to his leadership roles at Vanderbilt-Ingram, Tansey has an active research lab that focuses on transcriptional dysregulation in cancer cells. 

“Shared resources provide Vanderbilt-Ingram Cancer Center investigators access to technologies, expertise, and a collaborative infrastructure that would be impractical to have in their own laboratories. Our shared resources are world-class in every respect, and each of them are backed by experienced teams of professionals dedicated to advancing and accelerating cancer discovery. I am honored and excited to oversee this vital and vibrant part of the Vanderbilt-Ingram Cancer Center mission,” said Tansey, who also serves as co-leader of the Genome Maintenance Research Program at Vanderbilt-Ingram. 

Translational Research, which is an essential component of Vanderbilt-Ingram and how findings in the lab are “translated” to clinical practice, was previously led by Park. With an ever-increasing number of opportunities to perform translational cancer research at Vanderbilt-Ingram, Douglas Johnson, MD, MSCI, professor of Medicine and the holder of the Susan and Luke Simons Directorship, has been named the next associate director for Translational Research.  

Johnson will oversee the implementation of emerging treatments and therapy advancements, such as cellular therapies, immunotherapies and targeted therapies. Johnson, who is clinical director of melanoma at Vanderbilt-Ingram, has expertise in this realm, having been an investigator on early clinical trials for immunotherapies and having recently implemented a tumor-infiltrating lymphocyte therapy service line for patients. 

“Vanderbilt-Ingram Cancer Center has incredible strengths in translating observations in the lab to the clinic, and from the clinic to the lab. I look forward to continuing to work with so many talented scientists and physicians in this role,” Johnson said. 

Douglas Kojetin, PhD, Ingram Associate Professor of Cancer Research and associate professor of Biochemistry, will join two other experts as co-leader of the Genome Maintenance Research Program. He joins Tansey and David Cortez, PhD, the Richard N. Armstrong PhD Professor of Innovation in Biochemistry, at the helm. The Genome Maintenance Research Program is focused on understanding how DNA is damaged, repaired, packaged, expressed and replicated. These are the processes that take place in carcinogenesis. 

“Dr. Kojetin will be an outstanding leader of the Genome Maintenance Program,” Cortez said. “His own research program is creative, rigorous and impactful. His thoughtfulness, enthusiasm and dedication to service will help our entire research community to make discoveries that reduce the suffering caused by cancer. I look forward to working with him.”  

Kristen Ciombor, MD, MSCI, has been named co-leader of the Gastrointestinal (GI) Cancer Research Program. She brings a wealth of knowledge to this role, having previously been co-leader of the Translational Research and Interventional Oncology Research Program. She is nationally and internationally recognized for her clinical research program and clinical expertise in colon cancer.

Ciombor also serves as the principal investigator for the NCI-funded National Clinical Trials Network (NCTN) Lead Academic Participating Site (LAPS) grant at Vanderbilt-Ingram. Ciombor will join Cathy Eng, MD, who has led the GI Research Program for seven years, as she transitions away from this role over the next six months to focus more on her role as associate director of Strategic Relations and Research Partnerships and the Young Adult Cancers Program at Vanderbilt-Ingram.  

Park said the four researchers have established track records that make them the perfect choice for their new respective leadership roles. 

“Drs. Tansey, Johnson, Kojetin and Ciombor are all highly respected cancer researchers with the leadership skills to effectively lead these areas at Vanderbilt-Ingram,” Park said. “Cancer encompasses a myriad of complicated diseases, and our investigators are approaching it from many fronts. The research areas these scientists lead, and their ability to cultivate interactions across and between programs, are integral to our mission of advancing treatments and improving outcomes for people with cancer.” 

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Some cancer patients experience durable remissions from immune checkpoint inhibitors that spur their T cells to attack cancer cells, but these immunotherapies can also cause reactions.

One of the adverse effects of these treatments is skin reactions known as cutaneous immune-related adverse events (cirAEs), although it is not known how often they morph into a chronic condition. Research led by investigators at Vanderbilt University Medical Center published in JAMA Dermatology provides insight into chronic cirAEs. They recommended long-term follow-up for patients by dermatologists familiar with cirAEs and consideration of corticosteroid-sparing treatment options.

“Understanding the potential for side effects to become long-lasting has been an important advance recently, and managing them more effectively is a key unmet need,” said the study’s corresponding author, Douglas Johnson, MD, MSCI, professor of Medicine, holder of the Susan and Luke Simons Directorship, and co-leader of the Translational Research and Interventional Oncology Research Program at Vanderbilt-Ingram Cancer Center.

The investigators reviewed the records of 318 patients from a previous study who had been treated with immune checkpoint inhibitors. Of that number, 100 or 31% developed cirAEs with the skin conditions becoming chronic for 24 of the patients — nearly 8% of the full cohort. The study looked at 21 of those patients who underwent detailed follow-up. Another 31 patients were added from Vanderbilt clinics who were treated for cirAEs.

The 52 patients had received either pembrolizumab, nivolumab, ipilimumab or anti-PD1 and CTLA4 combination therapy.

The types of skin reactions varied, with 15 experiencing pruritus or itchy skin, 12 experienced morbilliform eruptions or drug-induced skin rashes, 12 experienced dermatitis or inflamed and scaly rashes, eight experienced bullous pemphigoid-like eruptions (fluid-filled blisters that resemble a rare autoimmune skin disease), five experienced eczema, four experienced lichenoid (flat-topped, scaly lesions), two experienced psoriasiform (breakouts that resemble psoriasis), and one experienced acneiform or acne-like eruptions.

The median duration of cirAE from treatment cessation was 446 days. Rare cases lasted more than five years.

Other Vanderbilt authors on the study included the study’s lead author, Kylie Fletcher, BS, Rachel Goodman, MD, MBA, J. Randall Patrinely, MD, MBA, and Anna Dewan, MD, MHS.

The research received support from Medical Scholars at Vanderbilt University School of Medicine, the Susan and Luke Simons Directorship, the James C. Bradford Jr. Fund in Melanoma Cancer Research and the Van Stephenson Memorial Cancer Research Fund.

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