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Clinical Trials Search at Vanderbilt-Ingram Cancer Center

A Study Evaluating an Advanced Pneumatic Compression Device Versus Usual Care for Treatment of Head and Neck Lymphedema

To compare the effectiveness of an APCD to Usual Care in the management of lymphedema and
fibrosis (LEF) in head and neck cancer (HNC) survivors.
Supportive Care
Not Available
Murphy, Barbara
Vanderbilt University


18 Years
Inclusion Criteria:

Age 18 years

Pathologically confirmed cancer of the HNC (larynx, pharynx, oral cavity, paranasal sinuses, major salivary glands, and HNC of unknown primary)

Completed curative intent cancer therapy with no evidence of active cancer at time of study enrollment

A diagnosis of either internal or external head and neck lymphedema

At least one core lymphedema associated symptom of 4 out of 10 at the time of study screening

Must be able and willing to participate in all aspects of the study and provide informed consent prior to study participation

Must be able to speak and understand English

Exclusion Criteria:

Previous APCD or Usual Care treatment for HNC LEF

Acute facial infection (e.g., facial or parotid gland abscess)

Known carotid sinus hypersensitivity syndrome

Symptomatic carotid artery disease, as manifested by a recent transient ischemic attack (within 30 days), ischemic stroke, or amaurosis fugax (monocular visual ischemic symptoms or blindness)

Internal jugular venous thrombosis (within 3 months)

Patient is pregnant or trying to become pregnant

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