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Clinical Trials Search at Vanderbilt-Ingram Cancer Center

Hypofractionated Radiotherapy Followed by Immediate Surgery for the Treatment of Soft Tissue Sarcomas

This phase II trial studies the effect of hypofractionated radiotherapy followed by immediate surgery in treating patients with soft tissue sarcoma. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects. Giving hypofractionated radiotherapy followed by immediate surgery may allow patients with sarcomas to be treated in a much more rapid and convenient fashion.
Sarcoma
Phase II
Adults
Not Available
Not Available
Shinohara, Eric
Local
Vanderbilt University
01-11-2021
Treatment
VICCSAR2062
NCT04506008

Eligibility

18 Years
BOTH
NO
Inclusion Criteria:

Histologic diagnosis of a soft tissue sarcoma of extremity, pelvis, chest wall or trunk/abdominal wall (non-retroperitoneal location)

Age >= 18 years

Eastern Cooperative Oncology Group (ECOG) performance status 0-2

Patient must be deemed able to comply with radiation treatment and surgery



Exclusion Criteria:

Patients with planned neoadjuvant chemotherapy

History of prior radiation to the same area to be irradiated

Pregnancy

Active collagen vascular disease or patients genetically predisposed to increased radiation related side effects

Patients with metastatic disease

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