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Clinical Trials Search at Vanderbilt-Ingram Cancer Center

Study of INBRX-109 in Conventional Chondrosarcoma

Randomized, blinded, placebo-controlled, Phase 2 study of INBRX-109 in unresectable or
metastatic conventional chondrosarcoma patients.
Phase II
Mol. targeted/Immunotherapy/Biologics
INBRX-109, Placebo
Davis, Elizabeth
Vanderbilt University


18 Years
Inclusion Criteria:

Conventional chondrosarcoma, unresectable (=inoperable) or metastatic.

Measurable disease by RECISTv1.1. Note: Tumor lesions located in a previously irradiated (or other locally treated) area will be considered measurable, provided there has been clear imaging-based progression of the lesions since the time of treatment.

Radiologic progression of disease per RECISTv1.1 criteria within 6 months prior to screening for this study.

Adequate hematologic, coagulation, hepatic and renal function as defined per protocol.

Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 or 1.

Estimated life expectancy of at least 12 weeks.

Availability of archival tissue or fresh cancer biopsy are mandatory.

Exclusion Criteria:

Any prior exposure to DR5 agonists.

Allergy or sensitivity to INBRX-109 or known allergies to CHO-produced antibodies.

Non-conventional chondrosarcoma, e.g., clear-cell, mesenchymal, extraskeletal myxoid, myxoid, and dedifferentiated chondrosarcoma.

Prior or concurrent malignancies. Exception: Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessments.

Chronic liver diseases. Exception: Patients with fatty liver disease are acceptable as long as adequate hepatic function as defined in the inclusion/exclusion criteria is confirmed.

Evidence or history of multiple sclerosis (MS) or other demyelinating disorders.

Other exclusion criteria per protocol.

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trials, call 615-936-8422.