Improving Care After Inherited Cancer Testing
Improving Care After Inherited Cancer Testing
The IMPACT Study seeks to refine and evaluate the effectiveness of interventions on improving guideline-adherent cancer risk management (CRM) and family communication (FC) of genetic test results for individuals with a documented pathogenic/likely pathogenic (P/LP) variant, and FC of family cancer history for individuals with a variant of uncertain significance (VUS) in an inherited cancer gene.
Miscellaneous
N/A
Adults
Not Available
Not Available
Pal, Tuya
Local
Vanderbilt University
08-05-2022
Eligibility
18 Years and older
ALL
true
Inclusion Criteria:
Randomized Controlled Trial Eligibility: All trial participants will be autonomous adults who are capable of participating in the study
Randomized Controlled Trial Eligibility: All trial participants will be autonomous adults who are capable of participating in the study
Inclusion Criteria:
Inclusion Criteria:
English-speaking men and women aged 18 years or older
English-speaking men and women aged 18 years or older
Not adopted (i.e., have information about their biological relatives)
Not adopted (i.e., have information about their biological relatives)
Have access to internet and a computer, tablet, or smartphone
Have access to internet and a computer, tablet, or smartphone
Documented pathogenic/likely pathogenic variant in an inherited cancer gene that has CRM guidelines listed in the National Comprehensive Cancer Network (NCCN) Genetic/Familial Panel focused on Breast, Ovarian, and Pancreatic or Colorectal cancers
Documented pathogenic/likely pathogenic variant in an inherited cancer gene that has CRM guidelines listed in the National Comprehensive Cancer Network (NCCN) Genetic/Familial Panel focused on Breast, Ovarian, and Pancreatic or Colorectal cancers
Must meet at least one of the following criteria: * Intervention A (GeneSHARE) criteria: Have at least one at-risk adult, living relative who either: * has not been told about the genetic test result by the participant * has not had their own genetic testing * Intervention B (LivingLabReport) criteria: Are non-adherent (i.e., either undertreatment or overtreatment) to at least one of the current NCCN CRM guidelines or if currently adherent, require ongoing cancer screening
Must meet at least one of the following criteria: * Intervention A (GeneSHARE) criteria: Have at least one at-risk adult, living relative who either: * has not been told about the genetic test result by the participant * has not had their own genetic testing * Intervention B (LivingLabReport) criteria: Are non-adherent (i.e., either undertreatment or overtreatment) to at least one of the current NCCN CRM guidelines or if currently adherent, require ongoing cancer screening
VUS Pilot Study Eligibility: All VUS pilot study participants will be autonomous adults who are capable of participating in the study. Eligibility criteria include:
VUS Pilot Study Eligibility: All VUS pilot study participants will be autonomous adults who are capable of participating in the study. Eligibility criteria include:
English-speaking men and women aged 18 years or older
English-speaking men and women aged 18 years or older
Not adopted (i.e., have information about their biological relatives)
Not adopted (i.e., have information about their biological relatives)
Have access to internet and a computer, tablet, or smartphone
Have access to internet and a computer, tablet, or smartphone
Documented VUS in an inherited cancer gene
Documented VUS in an inherited cancer gene
Randomized Controlled Trial Eligibility: All trial participants will be autonomous adults who are capable of participating in the study
Randomized Controlled Trial Eligibility: All trial participants will be autonomous adults who are capable of participating in the study
Inclusion Criteria:
Inclusion Criteria:
English-speaking men and women aged 18 years or older
English-speaking men and women aged 18 years or older
Not adopted (i.e., have information about their biological relatives)
Not adopted (i.e., have information about their biological relatives)
Have access to internet and a computer, tablet, or smartphone
Have access to internet and a computer, tablet, or smartphone
Documented pathogenic/likely pathogenic variant in an inherited cancer gene that has CRM guidelines listed in the National Comprehensive Cancer Network (NCCN) Genetic/Familial Panel focused on Breast, Ovarian, and Pancreatic or Colorectal cancers
Documented pathogenic/likely pathogenic variant in an inherited cancer gene that has CRM guidelines listed in the National Comprehensive Cancer Network (NCCN) Genetic/Familial Panel focused on Breast, Ovarian, and Pancreatic or Colorectal cancers
Must meet at least one of the following criteria: * Intervention A (GeneSHARE) criteria: Have at least one at-risk adult, living relative who either: * has not been told about the genetic test result by the participant * has not had their own genetic testing * Intervention B (LivingLabReport) criteria: Are non-adherent (i.e., either undertreatment or overtreatment) to at least one of the current NCCN CRM guidelines or if currently adherent, require ongoing cancer screening
Must meet at least one of the following criteria: * Intervention A (GeneSHARE) criteria: Have at least one at-risk adult, living relative who either: * has not been told about the genetic test result by the participant * has not had their own genetic testing * Intervention B (LivingLabReport) criteria: Are non-adherent (i.e., either undertreatment or overtreatment) to at least one of the current NCCN CRM guidelines or if currently adherent, require ongoing cancer screening
VUS Pilot Study Eligibility: All VUS pilot study participants will be autonomous adults who are capable of participating in the study. Eligibility criteria include:
VUS Pilot Study Eligibility: All VUS pilot study participants will be autonomous adults who are capable of participating in the study. Eligibility criteria include:
English-speaking men and women aged 18 years or older
English-speaking men and women aged 18 years or older
Not adopted (i.e., have information about their biological relatives)
Not adopted (i.e., have information about their biological relatives)
Have access to internet and a computer, tablet, or smartphone
Have access to internet and a computer, tablet, or smartphone
Documented VUS in an inherited cancer gene
Documented VUS in an inherited cancer gene
