Hypofractionated Radiotherapy Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas
Hypofractionated Radiotherapy Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas
The trial will use neoadjuvant hypofractionated radiotherapy followed by surgical resection in the treatment for soft tissue sarcoma. It will allow patients to be treated over a shorter course (5 or 15 days of radiation) compared to the traditional 5 week regimen. It is proposed that this will be possible without increasing the risk of wound complication or local recurrence compared with a traditional 5 week course of pre-operative radiation.
Sarcoma
Phase II
Adults
Not Available
Not Available
Shinohara, Eric
Local
Vanderbilt University
01-11-2021
Eligibility
18 Years and older
ALL
false
Inclusion Criteria:
Histologic diagnosis of a soft tissue sarcoma of extremity, pelvis, chest wall or trunk/abdominal wall (non-retroperitoneal location)
Histologic diagnosis of a soft tissue sarcoma of extremity, pelvis, chest wall or trunk/abdominal wall (non-retroperitoneal location)
ECOG performance status 0-2
ECOG performance status 0-2
Patient must be deemed able to comply with radiation treatment and surgery
Patient must be deemed able to comply with radiation treatment and surgery
Exclusion Criteria:
History of prior radiation to the same area to be irradiated
History of prior radiation to the same area to be irradiated
Pregnancy
Pregnancy
Active collagen vascular disease or patients genetically predisposed to increased radiation related side effects
Active collagen vascular disease or patients genetically predisposed to increased radiation related side effects
Histologic diagnosis of a soft tissue sarcoma of extremity, pelvis, chest wall or trunk/abdominal wall (non-retroperitoneal location)
Histologic diagnosis of a soft tissue sarcoma of extremity, pelvis, chest wall or trunk/abdominal wall (non-retroperitoneal location)
ECOG performance status 0-2
ECOG performance status 0-2
Patient must be deemed able to comply with radiation treatment and surgery
Patient must be deemed able to comply with radiation treatment and surgery
Exclusion Criteria:
History of prior radiation to the same area to be irradiated
History of prior radiation to the same area to be irradiated
Pregnancy
Pregnancy
Active collagen vascular disease or patients genetically predisposed to increased radiation related side effects
Active collagen vascular disease or patients genetically predisposed to increased radiation related side effects
