Cancer Health Outcomes & Control Research Program

The Cancer Health Outcomes and Control Program conducts research aimed at reducing the burden of cancer across the entire cancer care continuum. The research efforts of this interdisciplinary, collaborative program center on the themes of:

Prevention and Early Detection
Treatment-Related Outcomes
Survivorship and Palliative Care

RESEARCH THEMES

The Cancer Health Outcomes and Control Program aims to achieve the goal of reducing the cancer burden through:

Prevention & Early Detection

Establishing and further developing population and community-based resources for research into prevention and early detection

Treatment-Related Outcomes

Identifying environmental, sociobehavioral and genetic factors that affect short- and long-term outcomes

Survivorship & Palliative Care

Understanding the scope of and developing interventions to prevent or ameliorate adverse long-term patient-centered outcomes following cancer diagnosis and treatment

Outcome Disparities

Assessing the magnitude and determinants of disparities in cancer control and outcomes associated with age, race, gender, geography and other group characteristics and developing interventions to decrease such disparities

Health Policy

Designing and testing healthcare practices and policies that improve access to and delivery of care to minimize the burden of cancer

Meet the Program Members

Stacie B. Dusetzina, Ph.D., Eric L. Grogan, M.D., M.P.H. and Daniel A. Barocas, M.D., M.P.H. co-lead the Cancer Health Outcomes and Control program. The program maintains close alliances with other cancer center programs, including population science partner program, Cancer Epidemiology, and the basic and clinical science programs. Extensive collaborations with community partners—including Meharry Medical College, Tennessee State University, federally qualified community health centers and oncologists at affiliate institutions, and other academic centers—extend the program's impact in the community and foster multi-institution research.

Program Leader

Stacie B. Dusetzina, Ph.D.

Program Leader

Eric L. Grogan, M.D., M.P.H.

Program Leader

Daniel A. Barocas, M.D., M.P.H.

All Program Members

Featured Publications

A Polygenic Risk Score for Prostate Cancer Risk Prediction.

Schaffer, K.R. (CO), Shi, M., Shelley, J.P., Tosoian, J.J. (CO), Kachuri, L., Witte, J.S. & Mosley, J.D.

JAMA Intern Med 2023; PMID:36877498.

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Use of Active Surveillance vs Definitive Treatment Among Men with Low- and Favorable Intermediate-Risk Prostate Cancer in the US Between 2010 and 2018.

Al Hussein Al Awamlh, B., Barocas, D.A. (CO), Zhu, A., Tosoian, J.J. (CO), Ponsky, L., Negoita, S. & Shoag, J.E.

JAMA Intern Med 2023; PMID:37010836.

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Effects of Specialist Palliative Care for Patients Undergoing Major Abdominal Surgery for Cancer: a Randomized Clinical Trial.

Shinall, M.C. (CO), Martin, S.F., Karlekar, M., Hoskins, A., Morgan, E., Kiehl, A., Bryant, P., Orun, O.M., Raman, R., Tillman, B.F., Hawkins, A.T., Brown, A.J., Bailey, C.E. (GI), Idrees, K. (GI), Chang, S.S., Smith, J.A., Tan, M.C.B. (GI), Magge, D., Penson, D. (CO) & Ely, E.W.

JAMA Surg 2023; PMID:37163249.

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The Impact of the Lung EDRN-CVC on Phase 1, 2, & 3 Biomarker Validation Studies.

Kammer, M.N., Deppen, S.A. (CO), Antic, S., Jamshedur Rahman, S.M., Eisenberg, R., Maldonado, F. (TR), Aldrich, M.C. (CE), Sandler, K.L. (CO), Landman, B., Massion, P.P. & Grogan, E.L. (CO).

Cancer Biomark 33(4):449-465, 2022; PMID:35491773.

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Association of Rurality With Annual Repeat Lung Cancer Screening in the Veterans Health Aadministration.

Spalluto, L.B. (CO), Lewis, J.A. (CO), Samuels, L.R., Callaway-Lane, C., Matheny, M.E., Denton, J., Robles, J.A., Dittus, R.S., Yankelevitz, D.F., Henschke, C.I., Massion, P.P., Moghanaki, D. & Roumie, C.L.

J Am Coll Radiol 19(1 Pt B):131-138, 2022; PMID:35033300.

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Association Between Treatment for Localized Prostate Cancer and Mental Health Outcomes.

Luckenbaugh, A.N., Wallis, C.J.D., Huang, L.C., Wittmann, D., Klaassen, Z., Zhao, Z., Koyama, T. (ZY), Laviana, A.A., Conwill, R., Goodman, M., Hamilton, A.S., Wu, X.C., Paddock, L.E., Stroup, A., Cooperberg, M.R., Hashibe, M., O'Neil, B.B., Kaplan, S.H., Greenfield, S., Hoffman, K.E., Penson, D.F. (CO) & Barocas, D.A. (CO).

J Urol :101097JU0000000000002370, 2022; PMID:34978488.

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Association Between Treatment for Localized Prostate Cancer and Mental Health Outcomes.

J Urol :101097JU0000000000002370, 2022; PMID:34978488.

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Linking Structural Racism and Discrimination and Breast Cancer Outcomes: a Social Genomics Approach.

Carlos, R.C., Obeng-Gyasi, S., Cole, S.W., Zebrack, B.J., Pisano, E.D., Troester, M.A., Timsina, L., Wagner, L.I., Steingrimsson, J.A., Gareen, I., Lee, C., Adams, A.S. & Wilkins, C.H. (CO).

J Clin Oncol :JCO2102004, 2022; PMID:35108027.

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Posttraumatic Stress Symptoms and Financial Toxicity Among Adolescent and Young Adult Oncology Patients and Their Caregivers at Cancer Diagnosis.

Baum, L.V., Koyama, T. (ZY), Schremp, E.A., Zhang, K., Rodweller, C.A., Roth, M.C., Compas, B.E. (CO) & Friedman, D.L. (CO).

Cancer 2022; PMID:35226364.

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Many Medicare Beneficiaries Do Not Fill High-Price Specialty Drug Prescriptions.

Dusetzina, S.B. (CO), Huskamp, H.A., Rothman, R.L., Pinheiro, L.C., Roberts, A.W., Shah, N.D., Walunas, T.L., Wood, W.A., Zuckerman, A.D., Zullig, L.L. & Keating, N.L.

Health Aff (Millwood) 41(4):487-496, 2022; PMID:35377748.

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The Association of Healthcare System Resources with Lung Cancer Screening Implementation: a Cohort Study.

Lewis, J.A. (CO), Samuels, L.R., Denton, J., Matheny, M.E., Maiga, A., Slatore, C.G., Grogan, E. (CO), Kim, J., Sherrier, R.H., Dittus, R.S., Massion, P.P., Keohane, L., Roumie, C.L. & Nikpay, S.

Chest 2022; PMID:35413280.

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Your Money or Your Life - the High Cost of Cancer Drugs Under Medicare Part D.

Dusetzina, S.B. (CO).

N Engl J Med 2022; PMID:35507526.

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Increasing Racial and Ethnic Diversity in Cancer Clinical Trials: an American Society of Clinical Oncology and Association of Community Cancer Centers Joint Research Statement.

Oyer, R.A., Hurley, P., Boehmer, L., Bruinooge, S.S., Levit, K., Barrett, N., Benson, A., Bernick, L.A., Byatt, L., Charlot, M., Crews, J., DeLeon, K., Fashoyin-Aje, L., Garrett-Mayer, E., Gralow, J.R., Green, S., Guerra, C.E., Hamroun, L., Hardy, C.M., Hempstead, B., Jeames, S., Mann, M., Matin, K., McCaskill-Stevens, W., Merrill, J., Nowakowski, G.S., Patel, M.I., Pressman, A., Ramirez, A.G., Segura, J., Segarra-Vasquez, B., Hanley Williams, J., Williams, J.E., Winkfield, K.M. (CO), Yang, E.S., Zwicker, V. & Pierce, L.J.

J Clin Oncol :JCO2200754, 2022; PMID:35588469.

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Long-Term Health Effects of Curative Therapies on Heart, Lungs, and Kidneys for Individuals with Sickle Cell Disease Compared to Those with Hematologic Malignancies.

Fitzhugh, C.D., Volanakis, E.J., Idassi, O., Duberman, J.A., DeBaun, M.R. & Friedman, D.L. (CO).

J Clin Med 11(11), 2022; PMID:35683502.

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The Intervention Probability Curve: Modeling the Practical Application of Threshold-Guided Decision Making, Evaluated in Lung, Prostate, and Ovarian Cancers.

Kammer, M.N., Rowe, D.J., Deppen, S.A. (CO), Grogan, E.L. (CO), Kaizer, A.M., Bar N, A.E. & Maldonado, F. (TR).

Cancer Epidemiol Biomarkers Prev 2022; PMID:35732292.

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Comparative Effectiveness of Postdischarge Smoking Cessation Interventions for Hospital Patients: the Helping HAND 4 Randomized Clinical Trial.

Rigotti, N.A., Chang, Y., Davis, E.M., Regan, S., Levy, D.E., Ylioja, T., Kelley, J.H.K., Notier, A.E., Gilliam, K., Douaihy, A.B., Singer, D.E. & Tindle, H.A. (CO).

JAMA Intern Med 2022; PMID:35759282.

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Evaluation of Trends in Oncology Drug Spending in Medicare, 2016 to 2020.

Kyle, M.A., Dusetzina, S.B. (CO) & Keating, N.L.

JAMA Netw Open 5(7):e2221468, 2022; PMID:35816318.

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A Population-Based Study of the Long-Term Risk of Infections Associated with Hospitalization in Childhood Cancer Survivors.

Chehab, L., Doody, D.R., Esbenshade, A.J. (CO), Guilcher, G.M.T., Dvorak, C.C., Fisher, B.T., Mueller, B.A., Chow, E.J. & Rossoff, J.

J Clin Oncol :JCO2200230, 2022; PMID:35878085.

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Reforming Patient Cost Sharing for Cancer Medications in Medicare Part D.

Hwang, T.J., Kesselheim, A.S. & Dusetzina, S.B. (CO).

JAMA Oncol 2022; PMID:35925591.

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The Fish Oil to Reduce Tobacco Use in Expectant Mothers (FORTUNE) Feasibility Trial.

Murff, H.J. (GI), Greevy, R.A., Sternlieb, S., Gilliam, K., King, S., Sanghani, R. & Tindle, H.A. (CO).

Am J Obstet Gynecol MFM :100707, 2022; PMID:35948268.

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Patient-Reported Outcomes After External Beam Radiotherapy with Low Dose-Rate Brachytherapy Boost Versus Radical Prostatectomy for Localized Prostate Cancer: Five-Year Results From a Prospective Comparative Effectiveness Study.

De, B., Pasalic, D., Barocas, D.A. (CO), Wallis, C.J.D., Huang, L.C., Zhao, Z., Koyama, T. (ZY), Tang, C., Conwill, R., Goodman, M., Hamilton, A.S., Wu, X.C., Paddock, L.E., Stroup, A., Cooperberg, M.R., Hashibe, M., O'Neil, B.B., Kaplan, S.H., Greenfield, S., Penson, D.F. (CO) & Hoffman, K.E.

J Urol :101097JU0000000000002902, 2022; PMID:36006050.

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Post-Traumatic Stress Symptoms in Adolescent Hodgkin Lymphoma Survivors: a Report from Children's Oncology Group AHOD0031.

Werk, R.S., Koyama, T. (ZY), Sun, L., Wolden, S., Kelly, K.M., Constine, L.S., Schwartz, C.L. & Friedman, D.L. (CO).

J Adolesc Young Adult Oncol 2022; PMID:36094417.

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Reducing Uncertainty in Cancer Risk Estimation for Patients with Indeterminate Pulmonary Nodules Using an Integrated Deep Learning Model.

Gao, R., Li, T., Tang, Y., Xu, K., Khan, M., Kammer, M., Antic, S.L., Deppen, S. (CO), Huo, Y., Lasko, T.A., Sandler, K.L. (CO), Maldonado, F. (TR) & Landman, B.A.

Comput Biol Med 150:106113, 2022; PMID:36198225.

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Prescription Drug Spending in Fee-for-Service Medicare, 2008-2019.

Dusetzina, S.B. (CO), Huskamp, H.A., Qin, X. & Keating, N.L.

JAMA 328(15):1515-1522, 2022; PMID:36255428.

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The Association Between Financial Toxicity and Treatment Regret in Men with Localized Prostate Cancer.

Joyce, D.D., Wallis, C.J.D., Huang, L.C., Hoffman, K.E., Zhao, Z., Koyama, T. (ZY), Goodman, M., Hamilton, A.S., Wu, X.C., Paddock, L.E., Stroup, A., Cooperberg, M.R., Hashibe, M., O'Neil, B.B., Kaplan, S.H., Greenfield, S., Penson, D.F. (CO) & Barocas, D.A. (CO).

JNCI Cancer Spectr 2022; PMID:36255249.

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Creating the Right Team to Ensure Equitable Cancer Care: Whose Job is it Anyway?

Winkfield, K.M. (CO) & Schlundt, D.G.

JCO Oncol Pract :OP2200711, 2022; PMID:36516367.

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Program News

September 3, 2021

Winkfield to direct Meharry-Vanderbilt Alliance

Karen Winkfield, MD, PhD, associate professor of Radiation Oncology at Wake Forest University, associate director for Community Outreach and Engagement, and director of the Office of Cancer Health Equity at Wake Forest Baptist Comprehensive Cancer Center, has been named the new executive director of the Meharry-Vanderbilt Alliance.

May 7, 2020

Study finds AI can categorize cancer risk of lung nodules

Computed tomography scans for people at risk for lung cancer lead to earlier diagnoses and improve survival rates, but they can also lead to overtreatment when suspicious nodules turn out to be benign.

April 9, 2020

Study tracks genomics of lung tumor behavior

A study by Vanderbilt researchers has identified genomic alterations in early stage adenocarcinomas of the lung that may indicate whether the lesions develop into aggressive tumors.

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