Chemical Synthesis and High-Throughput Analytics Shared Resource
Overview
The Chemical Synthesis and High-Throughput Analytics Shared Resource provides investigators with integrated chemistry, assay development, and screening capabilities for the discovery and application of chemical tools. The resource supports projects ranging from pilot assay development and compound screening to hit validation, optimization, and chemical synthesis, allowing researchers to explore biological pathways and evaluate potential therapeutic targets. The Chemical Synthesis and High-Throughput Analytics Shared Resource combines expertise in chemical biology with advanced high-throughput technologies to help investigators move efficiently from experimental concept to actionable results. These capabilities support both mechanism-based studies and the development of new chemical probes and candidate compounds.
Directors
Alex Waterson, PhD
Co-Director
Joshua Bauer, PhD
Co-Director
Services
Chemical Synthesis
- Small-molecule design and synthesis
- Peptide synthesis
- Chemical probe design and synthesis
- Synthesis of literature and patented compounds
- Compound library design and synthesis
- Medicinal chemistry support
- Hit-to-lead optimization
- HPLC purification
- NMR and Mass Spectrometry analytical support
High-Throughput Screening
- Compound distribution, storage, and management
- Assay development and optimization
- Advanced liquid handling and lab automation
- Compound and drug screening
- Functional genomics screening (siRNA, CRISPR, ORFeome)
- Phenotypic screening
- High-content imaging
- 3D culture and organoid screening
- Hit identification and validation
- SAR and Hit-to-lead optimization support
- Screening data analysis
Contact Information
For more information about chemical synthesis services, please email Plamen Christov.
For more information about high-throughput screening services, please email us.