A Study to Evaluate the Safety and Tolerability of the Covalent Phosphoinositide-3-Kinase (PI3K)-Alpha Inhibitor, TOS-358, in Adult Subjects with Select Solid Tumors
Multiple Cancer Types
Breast,
Cervical,
Gastrointestinal,
Gynecologic,
Head/Neck,
Lung,
Phase I,
Urologic
I
Abramson, Vandana
NCT05683418
VICC-DTPHI23103
A Randomized, Open-Label Phase 3 Study of Amivantamab + FOLFIRI Versus Cetuximab/Bevacizumab + FOLFIRI in Participants with KRAS/NRAS and BRAF Wild-Type Recurrent, Unresectable or Metastatic Colorectal Cancer Who Have Received Prior Chemotherapy
Multiple Cancer Types
Colon,
Rectal
III
Eng, Cathy
NCT06750094
VICC-DTGIT24167
An International, Prospective, Open-Label, Multi-Center, Randomized Phase III Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan (AAA617) Versus Observation to Delay Castration or Disease Recurrence in Adult Male Patients with Prostate-Specific Membrane Antigen (PSMA) Positive Oligometastatic Prostate Cancer (OMPC)
Not Available
III
Schaffer, Kerry
NCT05939414
VICC-DTURO23342
A Phase 1/2 Study of BMS-986340 as Monotherapy and in Combination with Nivolumab or Docetaxel in Participants with Advanced Solid Tumors
Multiple Cancer Types
Bladder,
Colon,
Esophageal,
Gastric/Gastroesophageal,
Head/Neck,
Kidney (Renal Cell),
Lung,
Ovarian,
Pancreatic,
Urologic
I/II
Berlin, Jordan
NCT04895709
VICC-DTPHI23183
Randomized Phase II Trial of Lutetium Lu 177 Dotatate Versus Everolimus in Somatostatin Receptor Positive Bronchial Neuroendocrine Tumors.
Lung
Lung
Lung
II
Ramirez, Robert
NCT04665739
SWOGTHOA021901
An Interventional, Phase 3, Double-Blind, Randomized Study to Evaluate the Efficacy and Safety of Pf-08634404 in Combination with Chemotherapy Versus Bevacizumab in Combination with Chemotherapy in Treatment-Nave Participants with Metastatic Colorectal Cancer
Colon
Colon
Colon
III
Eng, Cathy
NCT07222800
VICCGI25060
A Multicenter, Randomized, Double-Blind, Phase 2/3 Study of Ficerafusp Alfa (BCA101) or Placebo in Combination with Pembrolizumab for First-Line Treatment of PD-L1-Positive, Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Head/Neck
Head/Neck
Head/Neck
II/III
Choe, Jennifer
NCT06788990
VICC-DTHAN23428
Hypofractionated Radiotherapy Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas
Sarcoma
Sarcoma
The trial will use neoadjuvant hypofractionated radiotherapy followed by surgical resection in the treatment for soft tissue sarcoma. It will allow patients to be treated over a shorter course (5 or 15 days of radiation) compared to the traditional 5 week regimen. It is proposed that this will be possible without increasing the risk of wound complication or local recurrence compared with a traditional 5 week course of pre-operative radiation.
Sarcoma
II
Shinohara, Eric
NCT04506008
VICCSAR2062
A Prospective, Randomized, Double-blind, Placebo-controlled, Multi-center Phase III Study to Evaluate the Efficacy and Safety of Mocravimod as Adjunctive and Maintenance Treatment in Adult Acute Myeloid Leukemia (AML) Patients Undergoing Allogeneic Hematopoietic Cell Transplantation (HCT)
Leukemia
Leukemia
Leukemia
III
Fedorov, Kateryna
NCT05429632
VICCCTT26030
A Phase II Study of Cabozantinib for Patients with Recurrent or Progressive Meningioma
Neuro-Oncology
Neuro-Oncology
Neuro-Oncology
II
Mohler, Alexander
NCT05425004
VICC-ITNEU23261
